Glucose tolerance test can clear up confusing results

Dear Dr. Roach: I’m confused by my blood glucose level and A1C. My blood glucose crept up after I started taking 40 mg of atorvastatin. My A1C is “normal,” so my doctor is unconcerned about the blood glucose reading.

When is it time to become concerned? Does A1C “trump” blood glucose results to the degree that the blood glucose test can be disregarded? If so, why bother to test blood glucose?

J.S. Diabetes can be diagnosed by blood sugars, which are a “snapshot” of blood sugar in time; by an A1C test, which looks at blood sugar averages over the past few months; or by a glucose tolerance test, which is a stress test on your pancreas’ ability to make insulin in response to a sugar load.

The A1C is most commonly used and is used to monitor blood sugar in people with diabetes.

People can have diabetes with a normal A1C, and even with normal fasting blood sugars. The glucose tolerance test is the most sensitive test for most people, since high blood sugar after eating usually happens long before high fasting sugars.

Blood sugar might be high for only a short period, so the A1C can be near normal. However, it would be very unusual to see a normal A1C in a person newly diagnosed with diabetes. It could happen if the change in blood sugar is very recent.

I hope your doctor really is concerned, even if they aren’t showing it. Atorvastatin can increase blood sugar, although not usually enough to make someone cross over into diabetes territory. The few times I order a glucose tolerance test are in cases such as yours, where the blood sugars are at odds with the A1C level.

Dear Dr. Roach: My husband was prescribed Singulair by his allergist and took it for two years. At the end of that time, he was diagnosed with depression and memory loss. His neurologist advised that he shouldn’t take it, but his pulmonologist recommends it. Do you take the warnings about the drug seriously? Most doctors don’t know about them.

S.R. Montelukast (Singulair) is commonly used for asthma and allergic rhinitis. I agree with you that many physicians are not aware of the boxed warning, which reads:

“Serious neuropsychiatric (NP) events have been reported with the use of montelukast. The types of events reported were highly variable and included, but were not limited to, agitation, aggression, depression, sleep disturbances and suicidal thoughts and behaviour (including suicide). The mechanisms underlying NP events associated with montelukast use are currently not well understood.”

Physicians should take boxed warnings seriously. That’s not to say this beneficial drug should not be used, but the FDA says, and I agree, that a person should be monitored for events like your husband’s. New depression while on this medicine should prompt discontinuation. Any type of depression, especially in older people, can be associated with memory changes.

I can’t say for sure whether your husband’s issues are caused by Singulair, but I would consider the neurologist’s advice to discontinue it to see whether he improves. The best estimate I could find for depression was that less than one per cent of people on this medicine were diagnosed with depression severe enough to warrant prescription drug treatment in the first year of taking it.

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